Ceramide EOP

Ingredient

Ceramide EOP

1,2 Hexanediol is an emollient and preservation material that helps improve the lubricity of formulas while imparting gentle antimicrobial effects that keep formulas safe.

Common Name

Ceramide 1

Category

Skin-identical ingredient

Benefits

Hydration

Protection

Barrier-repair

Anti-aging

Performance Rating

Exceptional

Chemical Structure

Due to technical limitations, an image cannot be inserted directly. However, the chemical structure of Ceramide EOP (Ceramide 1) consists of a sphingosine base linked to a very long-chain fatty acid (usually 30-32 carbon atoms) through an amide bond, with an additional ester-linked fatty acid at the ω-position.

Quick Summary Benefits

Strengthens skin barrier function

Improves skin hydration and moisture retention

Reduces transepidermal water loss (TEWL)

Enhances skin elasticity and firmness

Protects against environmental stressors

Use & Background in Skincare

Ceramide EOP, also known as Ceramide 1, is a crucial component of the skin's natural barrier. It plays a vital role in maintaining skin hydration, protecting against environmental damage, and supporting overall skin health. Ceramide EOP is widely used in skincare products for its exceptional ability to restore and maintain the skin's protective barrier.

Detailed Description

Ceramide EOP is a long-chain ceramide that belongs to the family of lipid molecules naturally present in the stratum corneum, the outermost layer of the skin. It is particularly important due to its unique structure and function within the skin barrier. Ceramide EOP consists of a sphingosine base linked to a very long-chain fatty acid (usually 30-32 carbon atoms) through an amide bond, with an additional ester-linked fatty acid at the ω-position [1].

The significance of Ceramide EOP in skincare stems from its crucial role in maintaining the skin's barrier function. Research has shown that Ceramide EOP, along with other ceramides, cholesterol, and free fatty acids, forms the lipid matrix that holds skin cells together, creating a waterproof barrier [2]. This barrier is essential for preventing water loss from the skin and protecting against external aggressors such as pollutants, microorganisms, and allergens.

Clinical studies have demonstrated the effectiveness of Ceramide EOP in improving skin hydration and barrier function. A study by Sahle et al. (2015) found that topical application of ceramides, including Ceramide EOP, significantly reduced transepidermal water loss and improved skin hydration in patients with dry skin conditions [3]. Furthermore, research by Tessema et al. (2017) showed that ceramide-containing formulations enhanced skin barrier recovery and improved skin elasticity in aging skin [4].

Comedogenicity

Ceramide EOP is considered non-comedogenic to very low comedogenic. According to the Acne Research Institute, ceramides have a comedogenicity rating of 0-1 on a scale of 0-5 [5].

Sustainability Notes

Ceramide EOP can be derived from natural sources or synthesized in laboratories. Sustainable production methods are being developed to reduce environmental impact. Some companies are exploring plant-based ceramide alternatives to enhance sustainability in skincare formulations.

How It's Made

Ceramide EOP is typically synthesized in laboratories to ensure purity and consistency. It can also be extracted from natural sources such as wheat germ oil or sweet potato, though synthetic versions are more common in skincare products due to their stability and effectiveness.

References

[1] Bouwstra, J. A., & Ponec, M. (2006). The skin barrier in healthy and diseased state. Biochimica et Biophysica Acta (BBA)-Biomembranes, 1758(12), 2080-2095. https://doi.org/10.1016/j.bbamem.2006.06.021

[2] Feingold, K. R., & Elias, P. M. (2014). Role of lipids in the formation and maintenance of the cutaneous permeability barrier. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 1841(3), 280-294. https://doi.org/10.1016/j.bbalip.2013.11.007

[3] Sahle, F. F., Gebre-Mariam, T., Dobner, B., Wohlrab, J., & Neubert, R. H. (2015). Skin diseases associated with the depletion of stratum corneum lipids and stratum corneum lipid substitution therapy. Skin Pharmacology and Physiology, 28(1), 42-55. https://doi.org/10.1159/000360009

[4] Tessema, E. N., Gebre-Mariam, T., Neubert, R. H., & Wohlrab, J. (2017). Potential applications of phyto-derived ceramides in improving epidermal barrier function. Skin Pharmacology and Physiology, 30(3), 115-138. https://doi.org/10.1159/000464337

[5] Acne Research Institute. (2023). Comedogenicity Ratings. Retrieved from https://www.acneresearchinstitute.com/comedogenicity-ratings