Ceramide NP

Ingredient

Ceramide NP

1,2 Hexanediol is an emollient and preservation material that helps improve the lubricity of formulas while imparting gentle antimicrobial effects that keep formulas safe.

Common Name

Ceramide 3

Category

Skin-identical ingredient

Benefits

Hydration

Protection

Barrier-repair

Anti-aging

Performance Rating

Exceptional

Chemical Structure

The chemical structure of Ceramide NP can be found on PubChem: Ceramide NP Structure

Quick Summary Benefits

Restores and maintains skin barrier function
Improves skin hydration and moisture retention
Reduces transepidermal water loss (TEWL)
Enhances skin's protective properties against environmental stressors
Helps in reducing signs of aging and improving skin elasticity

Use & Background in Skincare

Ceramide NP is a crucial component of the skin's natural lipid barrier. It plays a vital role in maintaining skin hydration, protecting against environmental damage, and supporting overall skin health. Ceramide NP has been widely incorporated into skincare products due to its ability to replenish and fortify the skin's protective barrier.

Detailed Description

Ceramide NP, also known as Ceramide 3, is a type of lipid molecule that occurs naturally in the uppermost layers of the skin. It belongs to a family of waxy lipid molecules that are essential components of the skin's barrier function. The "NP" in its name stands for "non-hydroxylated phytosphingosine," which refers to its specific molecular structure [1].

Ceramides make up about 50% of the lipids in the stratum corneum, the outermost layer of the skin. They play a crucial role in maintaining the skin's barrier function, which is essential for retaining moisture and protecting against environmental stressors. When the skin's barrier is compromised, it can lead to various skin issues, including dryness, sensitivity, and increased susceptibility to irritants and pathogens [2].

Clinical studies have demonstrated the efficacy of Ceramide NP in improving skin hydration and barrier function. A study published in the Journal of Cosmetic Dermatology found that topical application of ceramide-containing products significantly improved skin hydration and reduced transepidermal water loss (TEWL) in participants with dry skin [3]. Another study in the International Journal of Cosmetic Science showed that ceramide-based moisturizers were effective in improving skin barrier function and reducing symptoms in patients with atopic dermatitis [4].

The effectiveness of Ceramide NP in skincare is attributed to its ability to integrate into the skin's lipid matrix, where it helps to form a protective barrier against moisture loss and external aggressors. This barrier-strengthening effect not only improves skin hydration but also contributes to overall skin health and appearance, including potential anti-aging benefits by maintaining skin elasticity and reducing the appearance of fine lines and wrinkles [5].

Comedogenicity

Comedogenicity: 0 (on a scale of 0-5)

Ceramide NP is considered non-comedogenic and is unlikely to clog pores or cause acne. Its molecular structure allows it to integrate into the skin without blocking pores [6].

Sustainability Notes

Ceramide NP can be derived from both natural and synthetic sources. While natural sources are often preferred, synthetic ceramides can offer more consistent quality and may be more sustainable in the long run. The sustainability of Ceramide NP largely depends on its sourcing and production methods employed by individual manufacturers.

How It's Made

Ceramide NP can be extracted from natural sources such as wheat germ or sweet potato, or synthesized in laboratories to mimic the structure of naturally occurring ceramides. The synthetic production often involves the use of biotechnology and fermentation processes to ensure purity and consistency.

References

[1] Meckfessel, M. H., & Brandt, S. (2014). The structure, function, and importance of ceramides in skin and their use as therapeutic agents in skin-care products. Journal of the American Academy of Dermatology, 71(1), 177-184.

[2] Coderch, L., López, O., de la Maza, A., & Parra, J. L. (2003). Ceramides and skin function. American Journal of Clinical Dermatology, 4(2), 107-129.

[3] Spada, F., Barnes, T. M., & Greive, K. A. (2018). Skin hydration is significantly increased by a cream formulated to mimic the skin's own natural moisturizing systems. Clinical, Cosmetic and Investigational Dermatology, 11, 491-497.

[4] Chamlin, S. L., Kao, J., Frieden, I. J., Sheu, M. Y., Fowler, A. J., Fluhr, J. W., ... & Elias, P. M. (2002). Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity. Journal of the American Academy of Dermatology, 47(2), 198-208.

[5] Tessema, E. N., Gebre-Mariam, T., Neubert, R. H., & Wohlrab, J. (2017). Potential applications of phyto-derived ceramides in improving epidermal barrier function. Skin Pharmacology and Physiology, 30(3), 115-138.

[6] Draelos, Z. D. (2018). The science behind skin care: Moisturizers. Journal of Cosmetic Dermatology, 17(2), 138-144.

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